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SAE2 / UBA2 Antibody (aa160-210)

Rabbit Polyclonal Antibody

     
  • WB - SAE2 / UBA2 Antibody (aa160-210) ALS12130
    Western blot of SAE2 in HeLa cell lysate using antibody at 1.0 ug/ml.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9UBT2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 71kDa
Dilution IHC-P (5 µg/ml), WB (0.5-2 µg/ml),
Additional Information
Gene ID 10054
Other Names SUMO-activating enzyme subunit 2, 6.3.2.-, Anthracycline-associated resistance ARX, Ubiquitin-like 1-activating enzyme E1B, Ubiquitin-like modifier-activating enzyme 2, UBA2, SAE2, UBLE1B
Target/Specificity A synthetic peptide within amino acid residues 160-210 of human SAE2 was used as the immunogen.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsSAE2 / UBA2 Antibody (aa160-210) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBA2
Synonyms SAE2, UBLE1B
Function The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention
Research Areas
Citations (0)

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Background

The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

References

Okuma T.,et al.Biochem. Biophys. Res. Commun. 254:693-698(1999).
Gong L.,et al.FEBS Lett. 448:185-189(1999).
Desterro J.M.P.,et al.J. Biol. Chem. 274:10618-10624(1999).
Slapak C.,et al.Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.
Wiemann S.,et al.Genome Res. 11:422-435(2001).

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$ 395.00
Cat# ALS12130
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