PRLR / Prolactin Receptor Antibody
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P16471 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Calculated MW | 70kDa |
Dilution | IHC-P (1-2.5 µg/ml) |
Gene ID | 5618 |
---|---|
Other Names | Prolactin receptor, PRL-R, PRLR |
Target/Specificity | Recognizes human Prolactin Receptor. |
Reconstitution & Storage | Short term +4°C (no longer than one week); Long term -20°C; Aliquot to avoid freeze/thaw cycles. |
Precautions | PRLR / Prolactin Receptor Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PRLR |
---|---|
Function | This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. |
Cellular Location | Membrane; Single-pass type I membrane protein |
Tissue Location | Expressed in breast, placenta, kidney, liver and pancreas. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
References
Boutin J.-M.,et al.Mol. Endocrinol. 3:1455-1461(1989).
Kline J.B.,et al.J. Biol. Chem. 274:35461-35468(1999).
Hu Z.-Z.,et al.J. Clin. Endocrinol. Metab. 84:1153-1156(1999).
Hu Z.Z.,et al.J. Biol. Chem. 276:41086-41094(2001).
Kline J.B.,et al.Mol. Endocrinol. 16:2310-2322(2002).
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