|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (10 µg/ml), WB (1:200),|
|Other Names||Corticosteroid 11-beta-dehydrogenase isozyme 2, 1.1.1.-, 11-beta-hydroxysteroid dehydrogenase type 2, 11-DH2, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type II, -HSD11 type II, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, 11-beta-HSD, HSD11B2, HSD11K|
|Target/Specificity||Recognizes human, mouse and rat 11 beta-HSD2. Other species have not been tested.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||HSD2 / HSD11B2 Antibody (aa25-40) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.|
|Cellular Location||Microsome. Endoplasmic reticulum|
|Tissue Location||Found in placenta, kidney, pancreas, prostate, ovary, small intestine and colon|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Albiston A.L.,et al.Mol. Cell. Endocrinol. 105:R11-R17(1994).
Agarwal A.K.,et al.Genomics 29:195-199(1995).
Brown R.W.,et al.Biochem. J. 313:1007-1017(1996).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Brown R.W.,et al.Biochem. J. 313:997-1005(1996).
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