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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   B2M / Beta 2 Microglobulin Antibody (clone 2213)   

B2M / Beta 2 Microglobulin Antibody (clone 2213)

Mouse Monoclonal Antibody

     
  • IHC - B2M / Beta 2 Microglobulin Antibody (clone 2213) ALS12181
    Anti-B2M antibody IHC of human liver.
  • IHC - B2M / Beta 2 Microglobulin Antibody (clone 2213) ALS12181
    Anti-B2M antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P61769
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2213
Calculated MW 14kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 567
Other Names Beta-2-microglobulin, Beta-2-microglobulin form pI 5.3, B2M
Target/Specificity Specific for human beta 2 microglobulin. B2M is the beta chain of MHC class I molecules. The precursor protein has a molecular weight of approximately 14 kD and is 119 amino acids in length.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsB2M / Beta 2 Microglobulin Antibody (clone 2213) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name B2M
Function Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Cellular Location Secreted. Cell surface. Note=Detected in serum and urine (PubMed:1336137, PubMed:7554280). {ECO:0000269|PubMed:7554280, ECO:0000269|Ref.6}
Research Areas
Citations (0)

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Background

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

References

Guessow D.,et al.J. Immunol. 139:3132-3138(1987).
He X.H.,et al.Sheng Wu Gong Cheng Xue Bao 20:99-103(2004).
Matsumoto K.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Tan J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Zhao Z.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12181
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