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TRIM1 / MID2 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UJV3 |
| Reactivity | Human, Mouse, Monkey |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 83kDa |
| Dilution | ELISA (1:32000), IHC-P (5 µg/ml), WB (1:32000) |
| Gene ID | 11043 |
|---|---|
| Other Names | Probable E3 ubiquitin-protein ligase MID2, 6.3.2.-, Midin-2, Midline defect 2, Midline-2, RING finger protein 60, Tripartite motif-containing protein 1, MID2, FXY2, RNF60, TRIM1 |
| Target/Specificity | Human MID2. This antibody is expected to recognise both human isoforms of this protein. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | TRIM1 / MID2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MID2 |
|---|---|
| Synonyms | FXY2, RNF60, TRIM1 |
| Function | E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29 (PubMed:35266954). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton Note=Microtubule-associated. |
| Tissue Location | Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May play a role in microtubule stabilization.
References
Perry J.,et al.Genomics 62:385-394(1999).
Buchner G.,et al.Hum. Mol. Genet. 8:1397-1407(1999).
Ross M.T.,et al.Nature 434:325-337(2005).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Short K.M.,et al.BMC Cell Biol. 3:1-1(2002).
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