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ADAP2 / CENTA2 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - ADAP2 / CENTA2 Antibody (C-Terminus) ALS12194
    Anti-ADAP2 / CENTA2 antibody IHC of human placenta.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q9NPF8
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 44kDa
Dilution ELISA (1:32000), IHC-P (5 µg/ml),
Additional Information
Other Names Arf-GAP with dual PH domain-containing protein 2, Centaurin-alpha-2, Cnt-a2, ADAP2, CENTA2
Target/Specificity Human ADAP2 / CENTA2.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsADAP2 / CENTA2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADAP2
Synonyms CENTA2
Function GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.
Cellular Location Cytoplasm. Cell membrane. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus
Tissue Location Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes Not detected in spinal cord, brain, stomach, trachea, colon, lymph node and bone marrow. EMBL; AJ238994; CAB88383.1; -; mRNA EMBL; AJ272195; CAB77266.1; -; mRNA EMBL; AJ242782; CAC40651.1; -; mRNA EMBL; BC033758; AAH33758.1; -; mRNA CCDS; CCDS11261.1; -. [Q9NPF8-1] RefSeq; NP_001333643.1; NM_001346714.1. [Q9NPF8-2] RefSeq; NP_060874.1; NM_018404.2. [Q9NPF8-1] UniGene; Hs.514063; - ProteinModelPortal; Q9NPF8; - SMR; Q9NPF8; - BioGrid; 120915; 12 IntAct; Q9NPF8; 3 STRING; 9606.ENSP00000329468; - iPTMnet; Q9NPF8; - PhosphoSitePlus; Q9NPF8; - BioMuta; ADAP2; - DMDM; 27923749; - PaxDb; Q9NPF8; - PeptideAtlas; Q9NPF8; - PRIDE; Q9NPF8; - ProteomicsDB; 81987; - ProteomicsDB; 81988; -. [Q9NPF8-2] DNASU; 55803; - Ensembl; ENST00000330889; ENSP00000329468; ENSG00000184060. [Q9NPF8-1] GeneID; 55803; - KEGG; hsa:55803; - UCSC; uc002hfx.4; human. [Q9NPF8-1] CTD; 55803; - DisGeNET; 55803; - EuPathDB; HostDB:ENSG00000184060.10; - GeneCards; ADAP2; - HGNC; HGNC:16487; ADAP2 MIM; 608635; gene neXtProt; NX_Q9NPF8; - OpenTargets; ENSG00000184060; - PharmGKB; PA26405; - eggNOG; KOG0703; Eukaryota eggNOG; COG5347; LUCA GeneTree; ENSGT00900000140892; - HOGENOM; HOG000006719; - HOVERGEN; HBG050888; - InParanoid; Q9NPF8; - PhylomeDB; Q9NPF8; - TreeFam; TF324540; - ChiTaRS; ADAP2; human GeneWiki; CENTA2; - GenomeRNAi; 55803; - PRO; PR:Q9NPF8; - Proteomes; UP000005640; Chromosome 17 Bgee; ENSG00000184060; - CleanEx; HS_ADAP2; - ExpressionAtlas; Q9NPF8; baseline and differential Genevisible; Q9NPF8; HS GO; GO:0005737; C:cytoplasm; IDA:UniProtKB GO; GO:0005740; C:mitochondrial envelope; ISS:UniProtKB GO; GO:0005886; C:plasma membrane; IDA:UniProtKB GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW GO; GO:0043533; F:inositol 1,3,4,5 tetrakisphosphate binding; IDA:UniProtKB GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; ISS:UniProtKB GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:UniProtKB GO; GO:0030674; F:protein binding, bridging; NAS:UniProtKB GO; GO:0007507; P:heart development; IEP:UniProtKB CDD; cd13252; PH1_ADAP; 1 CDD; cd01251; PH2_ADAP; 1 Gene3D; 2.30.29.30; -; 2 Gene3D; 3.30.40.160; -; 1 InterPro; IPR037278; ARFGAP/RecO InterPro; IPR001164; ArfGAP_dom InterPro; IPR038508; ArfGAP_dom_sf InterPro; IPR011993; PH-like_dom_sf InterPro; IPR037849; PH1_ADAP InterPro; IPR037851; PH2_ADAP InterPro; IPR001849; PH_domain Pfam; PF01412; ArfGap; 1 Pfam; PF00169; PH; 2 PRINTS; PR00405; REVINTRACTNG SMART; SM00105; ArfGap; 1 SMART; SM00233; PH; 2 SUPFAM; SSF57863; SSF57863; 1 PROSITE; PS50115; ARFGAP; 1 PROSITE; PS50003; PH_DOMAIN; 2 1: Evidence at protein level; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; GTPase activation; Membrane; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger CHAIN 1 381 Arf-GAP with dual PH domain-containing protein 2 /FTId=PRO_0000074206 DOMAIN 9 131 Arf-GAP. {ECO:0000255|PROSITE- ProRule:PRU00288} DOMAIN 132 233 PH 1. {ECO:0000255|PROSITE- ProRule:PRU00145} DOMAIN 255 361 PH 2. {ECO:0000255|PROSITE- ProRule:PRU00145} ZN_FING 25 48 C4-type. {ECO:0000255|PROSITE- ProRule:PRU00288} VAR_SEQ 269 269 Missing (in isoform 2) /FTId=VSP_011180 CONFLICT 12 12 L -> P (in Ref. 3; CAC40651) SEQUENCE 381 AA; 44349 MW; 4FAE208072A92C01 CRC64; MGDRERNKKR LLELLRAPDT GNAHCADCGA ADPDWASYKL GIFICLNCCG VHRNFPDISR VKSVRLDFWD DSIVEFMIHN GNLRVKAKFE ARVPAFYYIP QANDCLVLKE QWIRAKYERR EFMADGETIS LPGNREGFLW KRGRDNSQFL RRKFVLLARE GLLKYFTKEQ GKSPKAVISI KDLNATFQTE KIGHPHGLQI TYRRDGHTRN LFVYHESGKE IVDWFNALRA ARLQYLKMAF PELPESELVP FLTRNYLKQG FMEKTGPKQK EPFKKRWFAL DCHERRLLYY KNPLDAFEQG QVFLGNKEQG YEAYEDLPKG IRGNRWKAGL TIVTPERRFV LTCPSEKEQQ EWLESLRGVL SSPLTPLNRL TASTESGRSS R
Research Areas
Citations (0)

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Background

GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.

References

Whitley P.,et al.Eur. J. Cell Biol. 81:222-230(2002).
Jenne D.E.,et al.Genomics 66:93-97(2000).
Bertsch U.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Hanck T.,et al.J. Neurochem. 88:326-336(2004).

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$ 425.00
Cat# ALS12194
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