|Application ||IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (5 µg/ml),|
|Other Names||Arf-GAP with dual PH domain-containing protein 2, Centaurin-alpha-2, Cnt-a2, ADAP2, CENTA2|
|Target/Specificity||Human ADAP2 / CENTA2.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ADAP2 / CENTA2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.|
|Cellular Location||Cytoplasm. Cell membrane. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus|
|Tissue Location||Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes Not detected in spinal cord, brain, stomach, trachea, colon, lymph node and bone marrow.|
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Provided below are standard protocols that you may find useful for product applications.
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.
Whitley P.,et al.Eur. J. Cell Biol. 81:222-230(2002).
Jenne D.E.,et al.Genomics 66:93-97(2000).
Bertsch U.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Hanck T.,et al.J. Neurochem. 88:326-336(2004).
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