|Application ||WB, IHC-P, E|
|Reactivity||Human, Rabbit, Pig, Horse, Xenopus, Dog|
|Dilution||IHC-P (5 µg/ml), WB (0.25-0.5 µg/ml),|
|Other Names||Eukaryotic translation initiation factor 4E transporter, 4E-T, eIF4E transporter, Eukaryotic translation initiation factor 4E nuclear import factor 1, EIF4ENIF1|
|Target/Specificity||Human EIF4ENIF1. This antibody is expected to recognise isoform 1 (NP_062817.2) and isoform b (NP_001157974.1). Reported variants represent identical protein (NP_062817.2; NP_001157973.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||EIF4ENIF1 / 4E-T Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Localization to nuclear foci and speckles requires active transcription|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Nucleoplasmic shuttling protein. Mediates the nuclear import of EIF4E by a piggy-back mechanism.
Dostie J.,et al.EMBO J. 19:3142-3156(2000).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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