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DKC1 / Dyskerin Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - DKC1 / Dyskerin Antibody (Internal) ALS12209
    Anti-DKC1 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession O60832
Reactivity Human, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 58kDa
Dilution ELISA (1:128000), IHC-P (5 µg/ml),
Additional Information
Gene ID 1736
Other Names H/ACA ribonucleoprotein complex subunit 4, 5.4.99.-, CBF5 homolog, Dyskerin, Nopp140-associated protein of 57 kDa, Nucleolar protein NAP57, Nucleolar protein family A member 4, snoRNP protein DKC1, DKC1, NOLA4
Target/Specificity Human DKC1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDKC1 / Dyskerin Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DKC1
Synonyms NOLA4
Function Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
Cellular Location Isoform 1: Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies)
Tissue Location Ubiquitously expressed.
Citations (0)

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Background

Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.

References

Heiss N.S.,et al.Nat. Genet. 19:32-38(1998).
Knight S.W.,et al.Am. J. Hum. Genet. 65:50-58(1999).
Hassock S.,et al.Genomics 55:21-27(1999).
Jiang W.,et al.Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
Angrisani A.,et al.Biochim. Biophys. Acta 1810:1361-1368(2011).

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$ 395.00
Cat# ALS12209
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