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DKC1 / Dyskerin Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | O60832 |
| Reactivity | Human, Monkey |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 58kDa |
| Dilution | ELISA (1:128000), IHC-P (5 µg/ml), |
| Gene ID | 1736 |
|---|---|
| Other Names | H/ACA ribonucleoprotein complex subunit 4, 5.4.99.-, CBF5 homolog, Dyskerin, Nopp140-associated protein of 57 kDa, Nucleolar protein NAP57, Nucleolar protein family A member 4, snoRNP protein DKC1, DKC1, NOLA4 |
| Target/Specificity | Human DKC1. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | DKC1 / Dyskerin Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DKC1 (HGNC:2890) |
|---|---|
| Synonyms | NOLA4 |
| Function | [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:25219674, PubMed:32554502). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (PubMed:25219674). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (PubMed:19179534, PubMed:25219674). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (PubMed:19179534). |
| Cellular Location | [Isoform 1]: Nucleus, nucleolus. Nucleus, Cajal body {ECO:0000250|UniProtKB:P40615} |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
References
Heiss N.S.,et al.Nat. Genet. 19:32-38(1998).
Knight S.W.,et al.Am. J. Hum. Genet. 65:50-58(1999).
Hassock S.,et al.Genomics 55:21-27(1999).
Jiang W.,et al.Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
Angrisani A.,et al.Biochim. Biophys. Acta 1810:1361-1368(2011).
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