|Application ||WB, IHC-P, E|
|Reactivity||Human, Monkey, Bovine|
|Dilution||IHC-P (5 µg/ml), WB (0.2-2 µg/ml),|
|Other Names||Neutrophil cytosol factor 1, NCF-1, 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NCF-47K, Neutrophil NADPH oxidase factor 1, Nox organizer 2, Nox-organizing protein 2, SH3 and PX domain-containing protein 1A, p47-phox, NCF1, NOXO2, SH3PXD1A|
|Target/Specificity||Human NCF1 / p47phox.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||NCF1 / p47phox / p47 phox Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).|
|Cellular Location||Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Detected in peripheral blood monocytes and neutrophils (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Volpp B.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:7195-7199(1989).
Volpp B.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:9563-9563(1989).
Lomax K.J.,et al.Science 245:409-412(1989).
Rodaway A.R.F.,et al.Mol. Cell. Biol. 10:5388-5396(1990).
Gorlach A.,et al.J. Clin. Invest. 100:1907-1918(1997).
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