|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Hamster, Dog|
|Dilution||ELISA (1:4000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml)|
|Other Names||Solute carrier family 12 member 4, Electroneutral potassium-chloride cotransporter 1, Erythroid K-Cl cotransporter 1, hKCC1, SLC12A4, KCC1|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||SLC12A4 / KCC1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
Gillen C.M.,et al.J. Biol. Chem. 271:16237-16244(1996).
Pellegrino C.M.,et al.Blood Cells Mol. Dis. 24:31-40(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Golding S.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.