|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Hamster, Dog|
|Dilution||ELISA (1:4000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml)|
|Other Names||Solute carrier family 12 member 4, Electroneutral potassium-chloride cotransporter 1, Erythroid K-Cl cotransporter 1, hKCC1, SLC12A4, KCC1|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||SLC12A4 / KCC1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes|
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Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
Gillen C.M.,et al.J. Biol. Chem. 271:16237-16244(1996).
Pellegrino C.M.,et al.Blood Cells Mol. Dis. 24:31-40(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Golding S.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
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