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SLC12A4 / KCC1 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UP95 |
| Reactivity | Human, Mouse, Rat, Hamster, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 121kDa |
| Dilution | ELISA (1:4000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml) |
| Gene ID | 6560 |
|---|---|
| Other Names | Solute carrier family 12 member 4, Electroneutral potassium-chloride cotransporter 1, Erythroid K-Cl cotransporter 1, hKCC1, SLC12A4, KCC1 |
| Target/Specificity | Human SLC12A4. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | SLC12A4 / KCC1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC12A4 (HGNC:10913) |
|---|---|
| Function | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitous (PubMed:8663127, PubMed:9516379). Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes (PubMed:9516379). This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS (PubMed:9516379). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
References
Gillen C.M.,et al.J. Biol. Chem. 271:16237-16244(1996).
Pellegrino C.M.,et al.Blood Cells Mol. Dis. 24:31-40(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Golding S.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
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