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SLC12A4 / KCC1 Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - SLC12A4 / KCC1 Antibody (Internal) ALS12235
    Antibody (0.3 ug/ml) staining of Human Heart lysate (35 ug protein in RIPA buffer).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9UP95
Reactivity Human, Mouse, Rat, Hamster, Dog
Host Goat
Clonality Polyclonal
Calculated MW 121kDa
Dilution ELISA (1:4000), IHC-P (5 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 6560
Other Names Solute carrier family 12 member 4, Electroneutral potassium-chloride cotransporter 1, Erythroid K-Cl cotransporter 1, hKCC1, SLC12A4, KCC1
Target/Specificity Human SLC12A4.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsSLC12A4 / KCC1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC12A4
Synonyms KCC1
Function Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes
Research Areas
Citations (0)

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Background

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.

References

Gillen C.M.,et al.J. Biol. Chem. 271:16237-16244(1996).
Pellegrino C.M.,et al.Blood Cells Mol. Dis. 24:31-40(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Golding S.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12235
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