|Application ||IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (2.5 µg/ml),|
|Other Names||Triggering receptor expressed on myeloid cells 2, TREM-2, Triggering receptor expressed on monocytes 2, TREM2|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||TREM2 / TREM-2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.|
|Tissue Location||Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.
Bouchon A.,et al.J. Immunol. 164:4991-4995(2000).
Begum N.A.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Paloneva J.,et al.Am. J. Hum. Genet. 71:656-662(2002).
Paloneva J.,et al.Am. J. Hum. Genet. 72:225-225(2003).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.