|Application ||IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (2.5 µg/ml),|
|Other Names||Triggering receptor expressed on myeloid cells 2, TREM-2, Triggering receptor expressed on monocytes 2, TREM2|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||TREM2 / TREM-2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.|
|Tissue Location||Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.|
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Provided below are standard protocols that you may find useful for product applications.
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.
Bouchon A.,et al.J. Immunol. 164:4991-4995(2000).
Begum N.A.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Paloneva J.,et al.Am. J. Hum. Genet. 71:656-662(2002).
Paloneva J.,et al.Am. J. Hum. Genet. 72:225-225(2003).
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