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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Aspartate Aminotransferase Antibody (aa157-167)   

Aspartate Aminotransferase Antibody (aa157-167)

Goat Polyclonal Antibody

     
  • WB - Aspartate Aminotransferase Antibody (aa157-167) ALS12253
    Antibody (0.01 ug/ml) staining of Human Liver lysate (35 ug protein in RIPA buffer).
  • IHC - Aspartate Aminotransferase Antibody (aa157-167) ALS12253
    Anti-GOT1 antibody IHC of human kidney.
  • IHC - Aspartate Aminotransferase Antibody (aa157-167) ALS12253
    Anti-GOT1 antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P17174
Reactivity Human, Rat, Hamster
Host Goat
Clonality Polyclonal
Calculated MW 46kDa
Dilution ELISA (1:4000), IHC-P (2.5-5 µg/ml), WB (0.01-0.1 µg/ml)
Additional Information
Gene ID 2805
Other Names Aspartate aminotransferase, cytoplasmic, cAspAT, 2.6.1.1, 2.6.1.3, Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, cCAT, Glutamate oxaloacetate transaminase 1, Transaminase A, GOT1
Target/Specificity Human GOT1.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsAspartate Aminotransferase Antibody (aa157-167) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GOT1
Function Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Background

Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

References

Bousquet-Lemercier B.,et al.Biochemistry 29:5293-5299(1990).
Wang C.Y.,et al.Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
Yu W.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).

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$ 395.00
Cat# ALS12253
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