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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PC / Pyruvate Carboxylase Antibody (Internal)   

PC / Pyruvate Carboxylase Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - PC / Pyruvate Carboxylase Antibody (Internal) ALS12273
    Antibody (0.03 ug/ml) staining of Mouse Liver lysate (35 ug protein in RIPA buffer).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P11498
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 130kDa
Dilution ELISA (1:16000), IHC-P (5 µg/ml), WB (0.03-0.1 µg/ml)
Additional Information
Gene ID 5091
Other Names Pyruvate carboxylase, mitochondrial, 6.4.1.1, Pyruvic carboxylase, PCB, PC
Target/Specificity Human PC / Pyruvate Carboxylase. All reported variants (NP_000911.2; NP_001035806.1; NP_071504.2) represent identical protein.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsPC / Pyruvate Carboxylase Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PC
Function Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
Cellular Location Mitochondrion matrix.
Research Areas
Citations (0)

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Background

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.

References

Wexler I.D.,et al.Biochim. Biophys. Acta 1227:46-52(1994).
Mackay N.,et al.Biochem. Biophys. Res. Commun. 202:1009-1014(1994).
Walker M.E.,et al.Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).

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$ 395.00
Cat# ALS12273
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