|Application ||WB, IHC-P, E, IHC-Fr|
|Reactivity||Human, Monkey, Dog, Cat|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Tryptase alpha/beta-1, Tryptase-1, 22.214.171.124, Tryptase I, Tryptase alpha-1, TPSAB1, TPS1, TPS2, TPSB1|
|Target/Specificity||Recognizes human mast cell tryptase, both alpha and beta isoforms. The antibody is an excellent marker for mast cells and does not bind to any other cell type in Immunohistochemistry. Species cross-reactivity: feline, canine and monkey.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||TPSAB1 / Mast Cell Tryptase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||TPS1, TPS2, TPSB1|
|Function||Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.|
|Cellular Location||Secreted. Note=Released from the secretory granules upon mast cell activation.|
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Provided below are standard protocols that you may find useful for product applications.
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
Miller J.S.,et al.J. Clin. Invest. 84:1188-1195(1989).
Schwartz L.B.,et al.Submitted (MAR-1990) to the EMBL/GenBank/DDBJ databases.
Vanderslice P.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:3811-3815(1990).
Pallaoro M.,et al.J. Biol. Chem. 274:3355-3362(1999).
Wang H.W.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
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