|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (10-20 µg/ml), WB (1 µg/ml),|
|Other Names||43 kDa receptor-associated protein of the synapse, RAPsyn, 43 kDa postsynaptic protein, Acetylcholine receptor-associated 43 kDa protein, RING finger protein 205, RAPSN, RNF205|
|Target/Specificity||Synthetic peptide corresponding to C-terminal residues of human RAPSN(43 kD receptor-associated protein of the synapse).|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||RAPSN Antibody (aa399-412) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytoskeleton. Note=Cytoplasmic surface of postsynaptic membranes|
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Provided below are standard protocols that you may find useful for product applications.
Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.
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Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Nam S.,et al.J. Biol. Chem. 284:8195-8206(2009).
Dunne V.,et al.J. Hum. Genet. 48:204-207(2003).
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