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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AKR1A1 Antibody (C-Terminus)   

AKR1A1 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - AKR1A1 Antibody (C-Terminus) ALS12442
    Anti-AKR1A1 antibody IHC of human kidney.
  • WB - AKR1A1 Antibody (C-Terminus) ALS12442
    HEK293 overexpressing AKR1A1 (RC200302) and probed with the antibody (mock transfection in first...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P14550
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Xenopus, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 37kDa
Dilution ELISA (1:16000), IHC-P (2.5 µg/ml), WB (0.5-2 µg/ml)
Additional Information
Gene ID 10327
Other Names Alcohol dehydrogenase [NADP(+)], 1.1.1.2, Aldehyde reductase, Aldo-keto reductase family 1 member A1, AKR1A1, ALDR1, ALR
Target/Specificity Human AKR1A1. Both reported variants (NP_006057.1and NP_697021.1) represent identical protein
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsAKR1A1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKR1A1
Synonyms ALDR1, ALR
Function Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Tissue Location Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung
Research Areas
Citations (0)

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Background

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).

References

Bohren K.M.,et al.J. Biol. Chem. 264:9547-9551(1989).
Fujii J.,et al.Cytogenet. Cell Genet. 84:230-232(1999).
Barski O.A.,et al.Genomics 60:188-198(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12442
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