|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml)|
|Other Names||STE20-related kinase adapter protein beta, STRAD beta, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein, CALS-21, ILP-interacting protein, Pseudokinase ALS2CR2, STRADB, ALS2CR2, ILPIP|
|Target/Specificity||Human STRADB. This is expected to recognise both human isoforms: ILPIP-alpha (NP_061041.2) and ILPIP-beta (AAF71042.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||STRADB / ALS2CR2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Highly expressed in heart, skeletal muscle, testis, liver and colon.|
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Provided below are standard protocols that you may find useful for product applications.
Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).
Hadano S.,et al.Genomics 71:200-213(2001).
Sanna M.G.,et al.J. Biol. Chem. 277:30454-30462(2002).
Zhang C.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
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