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GLI2 Antibody (aa46-60)

Rabbit Polyclonal Antibody

     
  • IHC - GLI2 Antibody (aa46-60) ALS12488
    Anti-GLI2 antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P10070
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 168kDa
Dilution ELISA (1:2000-1:12000), IHC-P (5 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 2736
Other Names Zinc finger protein GLI2, GLI family zinc finger protein 2 {ECO:0000312|HGNC:HGNC:4318}, Tax helper protein, GLI2 (HGNC:4318)
Target/Specificity Amino acids 46-60 of human Gli-2 (isoform a).
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsGLI2 Antibody (aa46-60) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GLI2 (HGNC:4318)
Function Functions as transcription regulator in the hedgehog (Hh) pathway (PubMed:18455992). Functions as transcriptional activator (PubMed:9557682, PubMed:19878745, PubMed:24311597). May also function as transcriptional repressor (By similarity). Requires STK36 for full transcriptional activator activity. Required for normal embryonic development (PubMed:15994174, PubMed:20685856).
Cellular Location Nucleus {ECO:0000250|UniProtKB:Q0VGT2}. Cytoplasm {ECO:0000250|UniProtKB:Q0VGT2}. Note=STK36 promotes translocation to the nucleus. In keratinocytes, it is sequestered in the cytoplasm by SUFU. In the absence of SUFU, it translocates to the nucleus. {ECO:0000250|UniProtKB:Q0VGT2} Isoform 2: Nucleus
Tissue Location Isoform 1 and isoform 4 are expressed in HTLV- 1-infected T-cell lines (at protein level). Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines. Isoform 3 and isoform 4 are weakly expressed in HTLV-1-infected T-cell lines.
Research Areas
Citations (0)

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Background

Has a dual function as a transcriptional activator and a repressor of the hedgehog (Hh) pathway. May play a role during embryogenesis.

References

Tanimura A.,et al.J. Virol. 72:3958-3964(1998).
Roessler E.,et al.Hum. Mol. Genet. 14:2181-2188(2005).
Hillier L.W.,et al.Nature 434:724-731(2005).
Tanimura A.,et al.J. Virol. 67:5375-5382(1993).
Ruppert J.M.,et al.Mol. Cell. Biol. 8:3104-3113(1988).

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$ 395.00
Cat# ALS12488
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