|Application ||IHC-P, E|
|Reactivity||Human, Rabbit, Monkey, Pig, Horse|
|Dilution||ELISA (1:16000), IHC-P (2.5 µg/ml),|
|Other Names||ADP-ribosylation factor-binding protein GGA3, Golgi-localized, gamma ear-containing, ARF-binding protein 3, GGA3, KIAA0154|
|Target/Specificity||Human GGA3. This antibody is expected to recognise both reported isoforms (NP_619525 and NP_054720)|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||GGA3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein|
|Tissue Location||Ubiquitously expressed.|
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Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
Dell'Angelica E.C.,et al.J. Cell Biol. 149:81-94(2000).
Boman A.L.,et al.Mol. Biol. Cell 11:1241-1255(2000).
Nagase T.,et al.DNA Res. 2:167-174(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
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