ERCC4 / XPF Antibody
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q92889 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Calculated MW | 104kDa |
Dilution | IHC-P (10 µg/ml), WB (1-2 µg/ml), |
Gene ID | 2072 |
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Other Names | DNA repair endonuclease XPF, 3.1.-.-, DNA excision repair protein ERCC-4, DNA repair protein complementing XP-F cells, Xeroderma pigmentosum group F-complementing protein, ERCC4, ERCC11, XPF |
Target/Specificity | Recognizes XPF. Species cross-reactivity: human. |
Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | ERCC4 / XPF Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ERCC4 {ECO:0000303|PubMed:8887684, ECO:0000312|HGNC:HGNC:3436} |
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Function | Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair. |
Cellular Location | Nucleus. Chromosome. Note=Localizes to sites of DNA damage |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.
References
Brookman K.W.,et al.Mol. Cell. Biol. 16:6553-6562(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Sijbers A.M.,et al.Cell 86:811-822(1996).
Cleaver J.E.,et al.Hum. Mutat. 14:9-22(1999).
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