MAOB / Monoamine Oxidase B Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | P27338 |
Reactivity | Human, Rabbit, Monkey, Pig, Horse, Bovine, Guinea Pig |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 59kDa |
Dilution | ELISA (1:32000), IHC-P (5 µg/ml), WB (1-3 µg/ml) |
Gene ID | 4129 |
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Other Names | Amine oxidase [flavin-containing] B, 1.4.3.4, Monoamine oxidase type B, MAO-B, MAOB |
Target/Specificity | Human MAOB. This antibody is not expected to cross-react with MAOA. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | MAOB / Monoamine Oxidase B Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MAOB (HGNC:6834) |
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Function | Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079). Preferentially degrades benzylamine and phenylethylamine (PubMed:11134050, PubMed:8665924, PubMed:8316221, PubMed:11049757, PubMed:20493079). |
Cellular Location | Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
References
Grimsby J.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:3637-3641(1991).
Bach A.W.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4934-4938(1988).
Chen K.,et al.J. Neurochem. 61:187-190(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
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