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UMOD / Uromodulin Antibody (clone 10.32)

Mouse Monoclonal Antibody

     
  • IHC - UMOD / Uromodulin Antibody (clone 10.32) ALS12525
    Anti-UMOD / Uromodulin antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, IHC-Fr
Primary Accession P07911
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 10.32
Calculated MW 70kDa
Dilution IHC-Fr, IHC-P (20 µg/ml),
Additional Information
Gene ID 7369
Other Names Uromodulin, Tamm-Horsfall urinary glycoprotein, THP, Uromodulin, secreted form, UMOD
Target/Specificity Anti-human Tamm-Horsfall protein (THP) is a monoclonal antibody which reacts with an epitope of the urinary mucoprotein. Tamm-Horsfall protein is a glycoprotein of approximately 80 kD containing up to 25% carbohydrate by weight.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsUMOD / Uromodulin Antibody (clone 10.32) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name UMOD
Function Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial.
Cellular Location Apical cell membrane; Lipid- anchor, GPI-anchor. Basolateral cell membrane; Lipid-anchor, GPI- anchor. Cell projection, cilium membrane. Note=Only a small fraction sorts to the basolateral pole of tubular epithelial cells compared to apical localization. Secreted into urine after cleavage. Colocalized with NPHP1 and KIF3A
Tissue Location Expressed in the tubular cells of the kidney (at protein level). Synthesized exclusively in the kidney Expressed exclusively by epithelial cells of the thick ascending limb of Henle's loop (TALH) and of distal convoluted tubule lumen Most abundant protein in normal urine
Research Areas
Citations (0)

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Background

Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial.

References

Pennica D.,et al.Science 236:83-88(1987).
Hession C.,et al.Science 237:1479-1484(1987).
Hart T.C.,et al.J. Med. Genet. 39:882-892(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).

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$ 395.00
Cat# ALS12525
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