|Application ||WB, IHC-P, E, IP, Flo|
|Dilution||IHC-P (20 µg/ml)|
|Other Names||Complement factor H, H factor 1, CFH, HF, HF1, HF2|
|Target/Specificity||Purified anti-human factor H (beta 1H) (139 kD) monoclonal antibody clone OX-24 inhibits the binding of factor H to surface bound C3. This antibody recognizes the human serum complement protein factor H and a 43-49kD truncated form of factor H present at.|
|Reconstitution & Storage||Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.|
|Precautions||CFH / Complement Factor H Antibody (clone OX-24) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HF, HF1, HF2|
|Function||Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.|
|Tissue Location||Expressed by the liver and secreted in plasma.|
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Provided below are standard protocols that you may find useful for product applications.
Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.
Ripoche J.,et al.Biochem. J. 249:593-602(1988).
Gregory S.G.,et al.Nature 441:315-321(2006).
Schulz T.F.,et al.Eur. J. Immunol. 16:1351-1355(1986).
Kristensen T.,et al.J. Immunol. 136:3407-3411(1986).
Estaller C.,et al.J. Immunol. 146:3190-3196(1991).
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