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APOC1 / Apolipoprotein C I Antibody

Goat Polyclonal Antibody

     
  • IHC - APOC1 / Apolipoprotein C I Antibody ALS12534
    Anti-APOC1 / Apolipoprotein CI antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P02654
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 9kDa
Dilution ELISA (1:100-1:10000), IHC-P (5 µg/ml), WB (1:100-1:10000)
Additional Information
Gene ID 341
Other Names Apolipoprotein C-I, Apo-CI, ApoC-I, Apolipoprotein C1, Truncated apolipoprotein C-I, APOC1
Target/Specificity Recognizes human Apo C-I in plasma and lipoproteins. Does not cross-react with plasma Apo A-I, Apo A-II, Apo B-100, Apo C-II, Apo C-III and Apo-E.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsAPOC1 / Apolipoprotein C I Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APOC1
Function Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
Cellular Location Secreted.
Tissue Location Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen
Research Areas
Citations (0)

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Background

Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.

References

Knott T.J.,et al.Nucleic Acids Res. 12:3909-3915(1984).
Lauer S.J.,et al.J. Biol. Chem. 263:7277-7286(1988).
Freitas E.M.,et al.DNA Seq. 9:89-100(1998).
Nickerson D.A.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12534
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