|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:128000), IHC-P (4 µg/ml), WB (0.1-0.3 µg/ml)|
|Other Names||Carnitine O-palmitoyltransferase 1, liver isoform, CPT1-L, 188.8.131.52, Carnitine O-palmitoyltransferase I, liver isoform, CPT I, CPTI-L, Carnitine palmitoyltransferase 1A, CPT1A, CPT1|
|Target/Specificity||Human CPT1A. This antibody is expected to recognize both reported isoforms (NP_001867.2; NP_001027017.1) but is not expected to recognise CPT1B.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CPT1A Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism.|
|Cellular Location||Mitochondrion outer membrane; Multi- pass membrane protein|
|Tissue Location||Strong expression in kidney and heart, and lower in liver and skeletal muscle|
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Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism.
Britton C.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:1984-1988(1995).
Gobin S.,et al.Hum. Genet. 111:179-189(2002).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Napal L.,et al.J. Mol. Biol. 354:751-759(2005).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
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