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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SLC22A17 Antibody (Internal)   

SLC22A17 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - SLC22A17 Antibody (Internal) ALS12619
    Anti-SLC22A17 antibody IHC of human brain, cerebellum.
  • IHC - SLC22A17 Antibody (Internal) ALS12619
    Anti-SLC22A17 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q8WUG5
Reactivity Human, Mouse, Rat, Hamster, Monkey, Pig, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 58kDa
Dilution ELISA (1:64000), IHC-P (2 µg/ml),
Additional Information
Gene ID 51310
Other Names Solute carrier family 22 member 17, 24p3 receptor, 24p3R, Brain-type organic cation transporter, Lipocalin-2 receptor, Neutrophil gelatinase-associated lipocalin receptor, NgalR, SLC22A17, BOCT, BOIT
Target/Specificity Human SLC22A17. This antibody is expected to recognize both reported isoforms NP_065105.2 and NP_057693.3).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsSLC22A17 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC22A17
Synonyms BOCT, BOIT
Function Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).
Cellular Location Cell membrane; Multi-pass membrane protein. Vacuole membrane; Multi-pass membrane protein. Note=Upon LCN2-binding, it is internalized
Tissue Location Expressed in brain.
Volume 50 µl
Research Areas
Citations (0)

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Background

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).

References

Fang W.K.,et al.Biochem. J. 403:297-303(2007).
Li W.B.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Heilig R.,et al.Nature 421:601-607(2003).
Bruess M.,et al.Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
Devireddy L.R.,et al.Cell 123:1293-1305(2005).

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$ 395.00
Cat# ALS12619
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