|Application ||WB, IHC-P, E|
|Dilution||IHC-P (5 µg/ml), WB (1 µg/ml),|
|Other Names||Hypoxia up-regulated protein 1, 150 kDa oxygen-regulated protein, ORP-150, 170 kDa glucose-regulated protein, GRP-170, HYOU1, GRP170, ORP150|
|Target/Specificity||Synthetic peptide corresponding to C-terminal residues of rat Hyou1(Hypoxia up-regulated 1) or Orp150 (150 kD oxygen-regulated protein precursor).|
|Reconstitution & Storage||Store at -20°C.|
|Precautions||HYOU1 / ORP150 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.|
|Cellular Location||Endoplasmic reticulum lumen.|
|Tissue Location||Highly expressed in tissues that contain well- developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers|
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Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
Ikeda J.,et al.Biochem. Biophys. Res. Commun. 230:94-99(1997).
Kaneda S.,et al.J. Biochem. 128:529-538(2000).
Takeuchi S.,et al.Protein J. 25:517-528(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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