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Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O14896 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 53kDa |
| Dilution | IHC-P (2.5 µg/ml), WB (0.2-1 µg/ml), |
| Gene ID | 3664 |
|---|---|
| Other Names | Interferon regulatory factor 6, IRF-6, IRF6 |
| Target/Specificity | Human IRF6. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | IRF6 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IRF6 |
|---|---|
| Function | Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). |
| Cellular Location | Nucleus. Cytoplasm Note=Translocates to nucleus in response to an activating signal |
| Tissue Location | Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity).
References
Grossman A.,et al.Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
Wang H.,et al.Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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