|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:8000), IHC-P (2.5 µg/ml), WB (1:8000)|
|Other Names||Poly [ADP-ribose] polymerase 2, PARP-2, hPARP-2, 184.108.40.206, ADP-ribosyltransferase diphtheria toxin-like 2, ARTD2, NAD(+) ADP-ribosyltransferase 2, ADPRT-2, Poly[ADP-ribose] synthase 2, pADPRT-2, PARP2, ADPRT2, ADPRTL2|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||PARP2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768).|
|Tissue Location||Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
Ame J.-C.,et al.J. Biol. Chem. 274:17860-17868(1999).
Johansson M.,et al.Genomics 57:442-445(1999).
Berghammer H.,et al.FEBS Lett. 449:259-263(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schreiber V.,et al.J. Biol. Chem. 277:23028-23036(2002).
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