|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Rabbit, Chicken, Sheep, Bovine|
|Other Names||14-3-3 protein eta, Protein AS1, YWHAH, YWHA1|
|Target/Specificity||Recognizes 14-3-3 eta in all mammals. It is a member of the 14-3-3 family which consists of 30 kD proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, ...|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||YWHAH / 14-3-3 Eta Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.|
|Tissue Location||Expressed mainly in the brain and present in other tissues albeit at lower levels|
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Provided below are standard protocols that you may find useful for product applications.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Swanson K.D.,et al.Biochim. Biophys. Acta 1216:145-148(1993).
Ichimura-Ohshima Y.,et al.J. Neurosci. Res. 31:600-605(1992).
Leffers H.,et al.Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
Muratake T.,et al.Mol. Neurobiol. 11:223-230(1995).
Muratake T.,et al.Genomics 36:63-69(1996).
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