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FAP-1 / PTPN13 Antibody (aa2290-2491)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q12923 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 277kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 5783 |
|---|---|
| Other Names | Tyrosine-protein phosphatase non-receptor type 13, 3.1.3.48, Fas-associated protein-tyrosine phosphatase 1, FAP-1, PTP-BAS, Protein-tyrosine phosphatase 1E, PTP-E1, hPTPE1, Protein-tyrosine phosphatase PTPL1, PTPN13, PNP1, PTP1E, PTPL1 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | FAP-1 / PTPN13 Antibody (aa2290-2491) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTPN13 |
|---|---|
| Synonyms | PNP1, PTP1E, PTPL1 |
| Function | Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317). |
| Cellular Location | Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium. Note=Colocalizes with F-actin (PubMed:10826496). Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover (PubMed:11356191) |
| Tissue Location | Expressed in keratinocytes (at protein level) (PubMed:29043977). Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).
References
Banville D.,et al.J. Biol. Chem. 269:22320-22327(1994).
Maekawa K.,et al.FEBS Lett. 337:200-206(1994).
Saras J.,et al.J. Biol. Chem. 269:24082-24089(1994).
Wang H.-Y.,et al.Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
Sato T.,et al.Science 268:411-415(1995).
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