|Dilution||IHC-P (10 µg/ml)|
|Other Names||Tyrosine-protein phosphatase non-receptor type 13, 188.8.131.52, Fas-associated protein-tyrosine phosphatase 1, FAP-1, PTP-BAS, Protein-tyrosine phosphatase 1E, PTP-E1, hPTPE1, Protein-tyrosine phosphatase PTPL1, PTPN13, PNP1, PTP1E, PTPL1|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||FAP-1 / PTPN13 Antibody (aa2290-2491) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PNP1, PTP1E, PTPL1|
|Function||Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).|
|Cellular Location||Cytoplasm, cytoskeleton. Nucleus. Cell projection, lamellipodium. Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover|
|Tissue Location||Present in most tissues with the exception of the liver and skeletal muscle. Most abundant in lung, kidney and fetal brain|
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Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317).
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Maekawa K.,et al.FEBS Lett. 337:200-206(1994).
Saras J.,et al.J. Biol. Chem. 269:24082-24089(1994).
Wang H.-Y.,et al.Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
Sato T.,et al.Science 268:411-415(1995).
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