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Myelin Basic Protein / MBP Antibody (N-Terminus, clone V/h5)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E, RIA |
|---|---|
| Primary Accession | P02686 |
| Reactivity | Human, Rabbit, Sheep, Bovine, Guinea Pig |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | V/h5 |
| Calculated MW | 33kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 4155 |
|---|---|
| Other Names | Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein, MBP |
| Target/Specificity | Recognizes predominantly residues 45-91 |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | Myelin Basic Protein / MBP Antibody (N-Terminus, clone V/h5) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MBP |
|---|---|
| Function | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. |
| Cellular Location | Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin |
| Tissue Location | MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
References
Carnegie P.R.,et al.Biochem. J. 123:57-67(1971).
Roth H.J.,et al.J. Neurosci. Res. 16:227-238(1986).
Kamholz J.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:4962-4966(1986).
Roth H.J.,et al.J. Neurosci. Res. 17:321-328(1987).
Streicher R.,et al.Biol. Chem. Hoppe-Seyler 370:503-510(1989).
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