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Myelin Basic Protein / MBP Antibody (N-Terminus, clone V/h5)

Mouse Monoclonal Antibody

     
  • IHC - Myelin Basic Protein / MBP Antibody (N-Terminus, clone V/h5) ALS12758
    Anti-Myelin Basic Protein antibody IHC of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E, RIA
Primary Accession P02686
Reactivity Human, Rabbit, Sheep, Bovine, Guinea Pig
Host Mouse
Clonality Monoclonal
Clone Names V/h5
Calculated MW 33kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 4155
Other Names Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein, MBP
Target/Specificity Recognizes predominantly residues 45-91
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsMyelin Basic Protein / MBP Antibody (N-Terminus, clone V/h5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBP
Function The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
Cellular Location Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin
Tissue Location MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system
Research Areas
Citations (0)

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Background

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

References

Carnegie P.R.,et al.Biochem. J. 123:57-67(1971).
Roth H.J.,et al.J. Neurosci. Res. 16:227-238(1986).
Kamholz J.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:4962-4966(1986).
Roth H.J.,et al.J. Neurosci. Res. 17:321-328(1987).
Streicher R.,et al.Biol. Chem. Hoppe-Seyler 370:503-510(1989).

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$ 395.00
Cat# ALS12758
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