|Application ||IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Chicken, Xenopus, Dog|
|Dilution||ELISA (1:1000), IHC-P (15 µg/ml),|
|Other Names||Brain-specific angiogenesis inhibitor 3, BAI3, KIAA0550|
|Target/Specificity||KLH conjugated synthetic peptide comprising amino acids 1506 - 1522 [CLNLPLDVQEGDFQTEV] of the human brain-specific angiogenesis inhibitor 3 (BAI3) protein.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ADGRB3 Antibody (aa1506-1522) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Strongly expressed in brain. Also detected in heart. Reduced expression in some glioblastoma cell lines|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma.
Shiratsuchi T.,et al.Cytogenet. Cell Genet. 79:103-108(1997).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
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