|Application ||IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Chicken, Xenopus, Dog|
|Dilution||ELISA (1:1000), IHC-P (15 µg/ml),|
|Other Names||Brain-specific angiogenesis inhibitor 3, BAI3, KIAA0550|
|Target/Specificity||KLH conjugated synthetic peptide comprising amino acids 1506 - 1522 [CLNLPLDVQEGDFQTEV] of the human brain-specific angiogenesis inhibitor 3 (BAI3) protein.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ADGRB3 Antibody (aa1506-1522) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Strongly expressed in brain. Also detected in heart. Reduced expression is observed in some glioblastoma cell lines|
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May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma.
Shiratsuchi T.,et al.Cytogenet. Cell Genet. 79:103-108(1997).
Nagase T.,et al.DNA Res. 5:31-39(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
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