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MBD2 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - MBD2 Antibody (Internal) ALS12862
    Anti-MBD2 antibody IHC of human colon.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9UBB5
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 43kDa
Dilution ELISA (1:64000), IHC-P (2.5 µg/ml),
Additional Information
Gene ID 8932
Other Names Methyl-CpG-binding domain protein 2, Demethylase, DMTase, Methyl-CpG-binding protein MBD2, MBD2
Target/Specificity Human MBD2. This antibody is expected to resognize isoform 1 (NP_003918.1) only.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsMBD2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBD2
Function Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Cellular Location Nucleus. Note=Nuclear, in discrete foci Detected at replication foci in late S phase
Tissue Location Highly expressed in brain, heart, kidney, stomach, testis and placenta.
Citations (0)

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Background

Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.

References

Hendrich B.,et al.Mol. Cell. Biol. 18:6538-6547(1998).
Hendrich B.,et al.Mamm. Genome 10:906-912(1999).
Bhattacharya S.K.,et al.Nature 397:579-583(1999).
Ng H.-H.,et al.Nat. Genet. 23:58-61(1999).
Tatematsu K.,et al.Genes Cells 5:677-688(2000).

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$ 395.00
Cat# ALS12862
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