|Application ||WB, IHC-P, E|
|Reactivity||Human, Monkey, Horse|
|Dilution||ELISA (1:32000), IHC-P (2.5 µg/ml), WB (1:32000)|
|Other Names||Neutrophil cytosol factor 4, NCF-4, Neutrophil NADPH oxidase factor 4, SH3 and PX domain-containing protein 4, p40-phox, p40phox, NCF4, SH3PXD4|
|Target/Specificity||Human NCF4. This antibody is expected to recognise both reported isoforms (NP_000622.2 and NP_038202.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||P40PHOX / NCF4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.|
|Cellular Location||Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein|
|Tissue Location||Expression is restricted to hematopoietic cells|
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Provided below are standard protocols that you may find useful for product applications.
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
Wientjes F.B.,et al.Biochem. J. 296:557-561(1993).
Zhan S.,et al.Blood 88:2714-2721(1996).
Hasebe T.,et al.FEBS Lett. 455:257-261(1999).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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