P40PHOX / NCF4 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q15080 |
Reactivity | Human, Monkey, Horse |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 39kDa |
Dilution | ELISA (1:32000), IHC-P (2.5 µg/ml), WB (1:32000) |
Gene ID | 4689 |
---|---|
Other Names | Neutrophil cytosol factor 4, NCF-4, Neutrophil NADPH oxidase factor 4, SH3 and PX domain-containing protein 4, p40-phox, p40phox, NCF4, SH3PXD4 |
Target/Specificity | Human NCF4. This antibody is expected to recognise both reported isoforms (NP_000622.2 and NP_038202.1). |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | P40PHOX / NCF4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NCF4 |
---|---|
Synonyms | SH3PXD4 |
Function | Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. |
Cellular Location | Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Peripheral membrane protein |
Tissue Location | Expression is restricted to hematopoietic cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
References
Wientjes F.B.,et al.Biochem. J. 296:557-561(1993).
Zhan S.,et al.Blood 88:2714-2721(1996).
Hasebe T.,et al.FEBS Lett. 455:257-261(1999).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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