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GABRB3 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - GABRB3 Antibody (Internal) ALS12868
    Anti-GABRB3 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P28472
Reactivity Human, Mouse, Rat, Hamster, Monkey, Horse, Dog
Host Goat
Clonality Polyclonal
Calculated MW 54kDa
Dilution ELISA (1:8000), IHC-P (2.5 µg/ml),
Additional Information
Gene ID 2562
Other Names Gamma-aminobutyric acid receptor subunit beta-3, GABA(A) receptor subunit beta-3, GABRB3
Target/Specificity Human GABRB3. This antibody is expected to recognize both reported isoforms (NP_000805.1, NP_068712.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsGABRB3 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GABRB3
Function Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.
Cellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P63079}
Research Areas
Citations (0)

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Background

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.

References

Wagstaff J.,et al.Genomics 11:1071-1078(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Kirkness E.F.,et al.J. Biol. Chem. 268:4420-4428(1993).

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$ 395.00
Cat# ALS12868
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