|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:8000), IHC-P (2.5 µg/ml), WB (1-3 µg/ml)|
|Other Names||CAP-Gly domain-containing linker protein 1, Cytoplasmic linker protein 1, Cytoplasmic linker protein 170 alpha-2, CLIP-170, Reed-Sternberg intermediate filament-associated protein, Restin, CLIP1, CYLN1, RSN|
|Target/Specificity||Human CLIP1 / CLIP170. This antibody is expected to recognize both reported isoforms (NP_002947.1; NP_937883.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CLIP1 / CLIP-170 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Associated with the cytoskeleton. Detected at the plus ends of microtubules in the cytosol, and close to plasma membrane ruffles. Associates with the membranes of intermediate macropinocytic vesicles|
|Tissue Location||Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.|
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Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.
Bilbe G.,et al.EMBO J. 11:2103-2113(1992).
Pierre P.,et al.Cell 70:887-900(1992).
Sahin U.,et al.Blood 100:4139-4145(2002).
Choi J.H.,et al.EMBO Rep. 3:988-994(2002).
Olsen J.V.,et al.Cell 127:635-648(2006).
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