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SELP / P-Selectin / CD62P Antibody (clone Psel.KO.2.5)

Mouse Monoclonal Antibody

     
  • IHC - SELP / P-Selectin / CD62P Antibody (clone Psel.KO.2.5) ALS12883
    Anti-CD62P antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IP, Flo
Primary Accession P16109
Reactivity Human, Pig
Host Mouse
Clonality Monoclonal
Clone Names Psel.KO.2.5
Calculated MW 91kDa
Dilution Flo (1:1-1:50), IHC-P (10 µg/ml),
Additional Information
Gene ID 6403
Other Names P-selectin, CD62 antigen-like family member P, Granule membrane protein 140, GMP-140, Leukocyte-endothelial cell adhesion molecule 3, LECAM3, Platelet activation dependent granule-external membrane protein, PADGEM, CD62P, SELP, GMRP, GRMP
Target/Specificity Recognizes the CD62P cell surface antigen, a 140kD glycoprotein also known as P-selectin. CD62P is expressed by activated platelets and endothelial cells, and plays an important role in adhesive processes between leucocytes and endothelial cells. To ...
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsSELP / P-Selectin / CD62P Antibody (clone Psel.KO.2.5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SELP
Synonyms GMRP, GRMP
Function Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface
Volume 250 µl
Research Areas
Citations (0)

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Background

Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

References

Johnston G.I.,et al.Cell 56:1033-1044(1989).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Fujimoto T.,et al.J. Biol. Chem. 268:11394-11400(1993).
Sako D.,et al.Cell 83:323-331(1995).

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$ 395.00
Cat# ALS12883
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