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SELP / P-Selectin / CD62P Antibody (clone Psel.KO.2.5)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IP, FC |
|---|---|
| Primary Accession | P16109 |
| Reactivity | Human, Pig |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | Psel.KO.2.5 |
| Calculated MW | 91kDa |
| Dilution | Flo (1:1-1:50), IHC-P (10 µg/ml), |
| Gene ID | 6403 |
|---|---|
| Other Names | P-selectin, CD62 antigen-like family member P, Granule membrane protein 140, GMP-140, Leukocyte-endothelial cell adhesion molecule 3, LECAM3, Platelet activation dependent granule-external membrane protein, PADGEM, CD62P, SELP, GMRP, GRMP |
| Target/Specificity | Recognizes the CD62P cell surface antigen, a 140kD glycoprotein also known as P-selectin. CD62P is expressed by activated platelets and endothelial cells, and plays an important role in adhesive processes between leucocytes and endothelial cells. To ... |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | SELP / P-Selectin / CD62P Antibody (clone Psel.KO.2.5) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SELP |
|---|---|
| Synonyms | GMRP, GRMP |
| Function | Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface |
| Volume | 250 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
References
Johnston G.I.,et al.Cell 56:1033-1044(1989).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Fujimoto T.,et al.J. Biol. Chem. 268:11394-11400(1993).
Sako D.,et al.Cell 83:323-331(1995).
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