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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HSPD1 / HSP60 Antibody   

HSPD1 / HSP60 Antibody

Goat Polyclonal Antibody

     
  • WB - HSPD1 / HSP60 Antibody ALS12900
    0
  • IHC - HSPD1 / HSP60 Antibody ALS12900
    Anti-HSPD1 antibody IHC of human adrenal.
  • IHC - HSPD1 / HSP60 Antibody ALS12900
    Anti-HSPD1 antibody IHC of human spleen.
  • IHC - HSPD1 / HSP60 Antibody ALS12900
    Anti-HSPD1 antibody IHC of human uterus.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession P10809
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Sheep, Xenopus, Bovine, Guinea Pig, Fish, Dog, Bacteria, Drosophila
Host Goat
Clonality Polyclonal
Calculated MW 61kDa
Dilution IHC-P (10 µg/ml), IP (1:100), WB (1:1000)
Additional Information
Gene ID 3329
Other Names 60 kDa heat shock protein, mitochondrial, 60 kDa chaperonin, Chaperonin 60, CPN60, Heat shock protein 60, HSP-60, Hsp60, HuCHA60, Mitochondrial matrix protein P1, P60 lymphocyte protein, HSPD1, HSP60
Target/Specificity Hsp60
Reconstitution & Storage Store at -20°C.
PrecautionsHSPD1 / HSP60 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSPD1
Synonyms HSP60
Function Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).
Cellular Location Mitochondrion matrix.
Volume 50 µl
Research Areas
Citations (0)

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Background

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

References

Jindal S.,et al.Mol. Cell. Biol. 9:2279-2283(1989).
Venner T.J.,et al.DNA Cell Biol. 9:545-552(1990).
Hansen J.J.,et al.Hum. Genet. 112:71-77(2003).
Tan J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 425.00
Cat# ALS12900
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