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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   BACE2 Antibody (C-Terminus)   

BACE2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - BACE2 Antibody (C-Terminus) ALS12953
    Western blot of BACE2 in human heart tissue lysate in the absence (A) or presence (B) of...
  • IHC - BACE2 Antibody (C-Terminus) ALS12953
    Anti-BACE2 antibody IHC of human pancreas.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9Y5Z0
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 56kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 25825
Other Names Beta-secretase 2, 3.4.23.45, Aspartic-like protease 56 kDa, Aspartyl protease 1, ASP1, Asp 1, Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site APP cleaving enzyme 2, Down region aspartic protease, DRAP, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, BACE2, AEPLC, ALP56, ASP21
Target/Specificity peptide corresponding to amino acids near the carboxy terminus of human BACE2
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsBACE2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BACE2
Synonyms AEPLC, ALP56, ASP21
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
Cellular Location Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface
Tissue Location Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
Research Areas
Citations (0)

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Background

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.

References

Yan R.,et al.Nature 402:533-537(1999).
Xin H.,et al.Biochim. Biophys. Acta 1501:125-137(2000).
Solans A.,et al.Cytogenet. Cell Genet. 89:177-184(2000).
Acquati F.,et al.FEBS Lett. 468:59-64(2000).
Bennett B.D.,et al.J. Biol. Chem. 275:20647-20651(2000).

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$ 395.00
Cat# ALS12953
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