|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Inactive caspase-12, CASP-12, CASP12|
|Target/Specificity||synthetic peptide corresponding to amino acids within the large cleavage product of murine caspase-12|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||CASP12 / Caspase 12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.|
|Tissue Location||Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis|
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Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Fischer H.,et al.Biochem. Biophys. Res. Commun. 293:722-726(2002).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Taylor T.D.,et al.Nature 440:497-500(2006).
Saleh M.,et al.Nature 429:75-79(2004).
Kachapati K.,et al.Hum. Mutat. 27:975-975(2006).
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