|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Sprouty-related, EVH1 domain-containing protein 1, Spred-1, hSpred1, SPRED1|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||SPRED1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).|
|Cellular Location||Cell membrane; Peripheral membrane protein Membrane, caveola; Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions|
|Tissue Location||Weakly expressed in embryonic cell line HEK293.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).
King J.A.J.,et al.Biochem. J. 388:445-454(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Engelhardt C.M.,et al.Histochem. Cell Biol. 122:527-538(2004).
Nonami A.,et al.Genes Cells 10:887-895(2005).
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