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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   CUL9 / Cullin 9 Antibody (clone PO69)   

CUL9 / Cullin 9 Antibody (clone PO69)

Mouse Monoclonal Antibody

     
  • WB - CUL9 / Cullin 9 Antibody (clone PO69) ALS13056
    HepG2 cell extract (left lane) or NIH 3T3 cell extract (right lane) probed with monoclonal...
  • IHC - CUL9 / Cullin 9 Antibody (clone PO69) ALS13056
    Anti-CUL9 / Cullin 9 antibody IHC of human placenta.
  • IHC - CUL9 / Cullin 9 Antibody (clone PO69) ALS13056
    Anti-CUL9 / Cullin 9 antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q8IWT3
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names PO69
Calculated MW 281kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 23113
Other Names Cullin-9, CUL-9, UbcH7-associated protein 1, p53-associated parkin-like cytoplasmic protein, CUL9, H7AP1, KIAA0708, PARC
Target/Specificity Human PARC peptide, corresponding to human amino acids AWEAKGPNMPGSC
Reconstitution & Storage +4°C. Store undiluted.
PrecautionsCUL9 / Cullin 9 Antibody (clone PO69) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CUL9
Synonyms H7AP1, KIAA0708, PARC
Function Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53- associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).
Cellular Location Cytoplasm.
Tissue Location Ubiquitously expressed in all tissues with highest expression in testis brain and kidney
Research Areas
Citations (0)

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Background

Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53- associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).

References

Nikolaev A.Y.,et al.Cell 112:29-40(2003).
Rose S.A.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS13056
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