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CUL9 / Cullin 9 Antibody (clone PO69)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q8IWT3 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | PO69 |
| Calculated MW | 281kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 23113 |
|---|---|
| Other Names | Cullin-9, CUL-9, UbcH7-associated protein 1, p53-associated parkin-like cytoplasmic protein, CUL9, H7AP1, KIAA0708, PARC |
| Target/Specificity | Human PARC peptide, corresponding to human amino acids AWEAKGPNMPGSC |
| Reconstitution & Storage | +4°C. Store undiluted. |
| Precautions | CUL9 / Cullin 9 Antibody (clone PO69) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CUL9 |
|---|---|
| Synonyms | H7AP1, KIAA0708, PARC |
| Function | Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Ubiquitously expressed in all tissues with highest expression in testis brain and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53- associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).
References
Nikolaev A.Y.,et al.Cell 112:29-40(2003).
Rose S.A.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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