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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   PPARD / PPAR Delta Antibody (C-Terminus)   

PPARD / PPAR Delta Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - PPARD / PPAR Delta Antibody (C-Terminus) ALS13078
    Anti-PPAR Delta antibody IHC of human prostate.
  • WB - PPARD / PPAR Delta Antibody (C-Terminus) ALS13078
    Staining (0.3 ug/ml) of Jurkat lysate (35 ug protein in RIPA buffer).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q03181
Reactivity Human, Mouse, Rat, Rabbit, Zebrafish, Hamster, Monkey, Pig, Chicken, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 50kDa
Dilution ELISA (1:16000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 5467
Other Names Peroxisome proliferator-activated receptor delta, PPAR-delta, NUCI, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, PPARD, NR1C2, PPARB
Target/Specificity Human PPARD. This antibody is expected to recognise isoform 1 (NP_006229) of PPAR delta, but not isoform 2, a shorter protein (NP_803184) with a different C-terminus.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsPPARD / PPAR Delta Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPARD
Synonyms NR1C2, PPARB
Function Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Cellular Location Nucleus.
Tissue Location Ubiquitous with maximal levels in placenta and skeletal muscle
Research Areas
Citations (0)

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Background

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.

References

Schmidt A.,et al.Mol. Endocrinol. 6:1634-1641(1992).
Skogsberg J.,et al.Int. J. Mol. Med. 6:73-81(2000).
Kobayashi T.,et al.FEBS Lett. 582:2737-2744(2008).
Cho M.-C.,et al.Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS13078
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