SERPINE1 / PAI-1 Antibody (Internal)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P, E |
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Primary Accession | P05121 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 45kDa |
Dilution | ELISA (1:32000), IHC-P (2.5 µg/ml), WB (0.1-0.3 µg/ml) |
Gene ID | 5054 |
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Other Names | Plasminogen activator inhibitor 1, PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1, SERPINE1, PAI1, PLANH1 |
Target/Specificity | Human SERPINE1 / PAI-1. This antibody is expected to recognise both reported isoforms. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | SERPINE1 / PAI-1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SERPINE1 |
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Synonyms | PAI1, PLANH1 |
Function | Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084). |
Cellular Location | Secreted. |
Tissue Location | Expressed in endothelial cells (PubMed:2430793, PubMed:3097076). Found in plasma, platelets, and hepatoma and fibrosarcoma cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
References
Pannekoek H.,et al.EMBO J. 5:2539-2544(1986).
Loskutoff D.J.,et al.Biochemistry 26:3763-3768(1987).
Ginsburg D.,et al.J. Clin. Invest. 78:1673-1680(1986).
Follo M.,et al.Gene 84:447-453(1989).
Strandberg L.,et al.Eur. J. Biochem. 176:609-616(1988).
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