|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:128000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)|
|Other Names||5-hydroxytryptamine receptor 3A, 5-HT3-A, 5-HT3A, 5-hydroxytryptamine receptor 3, 5-HT-3, 5-HT3R, Serotonin receptor 3A, Serotonin-gated ion channel receptor, HTR3A, 5HT3R, HTR3|
|Target/Specificity||Human HTR3A / 5-HT3A. This antibody is expected to recognise all three reported isoforms (NP_998786.2; NP_000860.2; NP_001155244.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||HTR3A / 5-HT3A Receptor Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.|
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Provided below are standard protocols that you may find useful for product applications.
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Miyake A.,et al.Mol. Pharmacol. 48:407-416(1995).
Belelli D.,et al.Mol. Pharmacol. 48:1054-1062(1995).
Bruess M.,et al.Ann. N. Y. Acad. Sci. 861:234-235(1998).
Bruess M.,et al.Neuropharmacology 39:308-315(2000).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
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