|Application ||WB, IHC-P, E, IP|
|Reactivity||Human, Mouse, Rat, Monkey, Pig, Horse, Bovine, Dog|
|Dilution||ELISA (1:64000), IHC-P (2.5 µg/ml), WB (0.01-0.03 µg/ml)|
|Other Names||Argininosuccinate synthase, 220.127.116.11, Citrulline--aspartate ligase, ASS1, ASS|
|Target/Specificity||Human ASS1. The variants represent identical protein (NP_000041.2 and NP_446464.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ASS1 / ASS Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.|
|Cellular Location||Cytoplasm, cytosol|
|Tissue Location||Expressed in adult liver.|
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Provided below are standard protocols that you may find useful for product applications.
Is indirectly involved in the control of blood pressure.
Bock H.-G.O.,et al.Nucleic Acids Res. 11:6505-6512(1983).
Freytag S.O.,et al.J. Biol. Chem. 259:3160-3166(1984).
Haeberle J.,et al.Hum. Genet. 110:327-333(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Jinno Y.,et al.J. Inherit. Metab. Dis. 8:157-159(1985).
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