|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Chicken, Xenopus, Bovine, Dog|
|Dilution||ELISA (1:128000), IHC-P (3.75 µg/ml), WB (0.1-0.3 µg/ml)|
|Other Names||Nucleolysin TIA-1 isoform p40, RNA-binding protein TIA-1, T-cell-restricted intracellular antigen-1, TIA-1, p40-TIA-1, TIA1|
|Target/Specificity||Human TIA1. This antibody is expected to recognise both reported isoforms (NP_071320.1 and NP_071505.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||TIA-1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.|
|Cellular Location||Cytoplasmic granule. Nucleus Note=Accumulates in cytoplasmic stress granules (SG) following cellular damage.|
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Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Tian Q.,et al.Cell 67:629-639(1991).
Kawakami A.,et al.J. Immunol. 152:4937-4945(1994).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Gilks N.,et al.Mol. Biol. Cell 15:5383-5398(2004).
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