|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Chicken, Xenopus, Bovine, Dog|
|Dilution||ELISA (1:128000), IHC-P (3.75 µg/ml), WB (0.1-0.3 µg/ml)|
|Other Names||Nucleolysin TIA-1 isoform p40, RNA-binding protein TIA-1, T-cell-restricted intracellular antigen-1, TIA-1, p40-TIA-1, TIA1|
|Target/Specificity||Human TIA1. This antibody is expected to recognise both reported isoforms (NP_071320.1 and NP_071505.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||TIA-1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.|
|Cellular Location||Cytoplasmic granule. Nucleus Note=Accumulates in cytoplasmic stress granules (SG) following cellular damage.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Tian Q.,et al.Cell 67:629-639(1991).
Kawakami A.,et al.J. Immunol. 152:4937-4945(1994).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Gilks N.,et al.Mol. Biol. Cell 15:5383-5398(2004).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.