|Application ||IHC-P, E|
|Reactivity||Human, Monkey, Horse|
|Dilution||ELISA (1:16000), IHC-P (3.75 µg/ml),|
|Other Names||C-type lectin domain family 2 member D, Lectin-like NK cell receptor, Lectin-like transcript 1, LLT-1, Osteoclast inhibitory lectin, CLEC2D, CLAX, LLT1, OCIL|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CLEC2D / OCIL / LLT1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLAX, LLT1, OCIL|
|Function||Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Cell surface Isoform 4: Endoplasmic reticulum.|
|Tissue Location||Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans.
Boles K.S.,et al.Immunogenetics 50:1-7(1999).
Hu Y.S.,et al.J. Bone Miner. Res. 19:89-99(2004).
Germain C.,et al.J. Biol. Chem. 285:36207-36215(2010).
Yang G.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).
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