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DGAT2 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - DGAT2 Antibody (Internal) ALS13111
    Anti-DGAT2 antibody IHC of human liver.
  • WB - DGAT2 Antibody (Internal) ALS13111
    Staining (0.5 ug/ml) of Human Liver lysate in the third lane (35 ug protein in RIPA buffer).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96PD7
Reactivity Human, Rabbit, Pig, Horse, Dog
Host Goat
Clonality Polyclonal
Calculated MW 44kDa
Dilution ELISA (1:128000), IHC-P (3.75 µg/ml), WB (0.3-1 µg/ml)
Additional Information
Gene ID 84649
Other Names Diacylglycerol O-acyltransferase 2, 2.3.1.20, Acyl-CoA retinol O-fatty-acyltransferase, ARAT, Retinol O-fatty-acyltransferase, 2.3.1.76, Diglyceride acyltransferase 2, DGAT2
Target/Specificity Human DGAT2. This antibody is not expected to cross-react with other DGAT members.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsDGAT2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DGAT2
Function Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet
Tissue Location Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin
Research Areas
Citations (0)

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Background

Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT).

References

Cases S.,et al.J. Biol. Chem. 276:38870-38876(2001).
Wakimoto K.,et al.Biochem. Biophys. Res. Commun. 310:296-302(2003).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Taylor T.D.,et al.Nature 440:497-500(2006).

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$ 395.00
Cat# ALS13111
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